Synvisc-One Injection Cost: $600-$1,745 (2026 Guide)

Q: Is Synvisc-One safe for patients with bird or egg allergies?

No. Synvisc-One is derived from avian sources (chicken/rooster combs) and is contraindicated in patients with allergies to birds, poultry, eggs, or feathers. If you have any such allergy, inform your provider before scheduling. The non-avian single-injection alternatives covered by Medicare are Durolane (HCPCS J7318) and Monovisc (J7327).

Q: What CPT and HCPCS codes are used for Synvisc-One billing?

Synvisc-One is billed using HCPCS code J7325 (Hyaluronan or derivative, Synvisc or Synvisc-One, for intra-articular injection, per 1 mg). One 6 mL / 48 mg syringe equals 48 units of J7325. The injection procedure itself is billed under CPT 20610 (arthrocentesis, aspiration and/or injection, major joint, without ultrasound guidance) or CPT 20611 (with ultrasound guidance). Both J7325 and CPT 20610/20611 are reimbursable under Medicare Part B when medical necessity criteria are met. --- ---

Key Takeaways

Synvisc-One self-pay cost ranges from $600 to $1,745 depending on whether you buy at a clinic (buy-and-bill) or retail pharmacy
With Medicare Part B, patients typically pay the 20% coinsurance — approximately $100–$200 after meeting the annual deductible
Synvisc-One is billed under HCPCS code J7325 (hylan G-F 20, 1 mg per unit; one injection = 48 units)
Synvisc-One is avian-derived (chicken/rooster comb) — patients with bird, egg, or poultry allergies must use a non-avian alternative such as Durolane or Monovisc
As a single-injection product, Synvisc-One requires only one office visit, saving the copay and time costs of 3–5 visit series brands
Discount programs such as SingleCare can reduce the retail pharmacy price from ~$1,640 to approximately $1,344 (SingleCare)

Synvisc-One is one of the most widely prescribed single-injection hyaluronic acid treatments for knee osteoarthritis in the United States. If you’re considering Synvisc-One — or your doctor has recommended it — understanding exactly what it costs with Medicare, private insurance, and self-pay is essential for planning your care.

This guide covers 2026 pricing across all scenarios, along with tips for reducing your out-of-pocket costs and a clear-eyed comparison to alternatives.

What Is Synvisc-One and Why It Costs What It Does

Synvisc-One is a single-injection viscosupplementation product manufactured by Sanofi (Genzyme). It contains hylan G-F 20, a cross-linked form of hyaluronan derived from avian sources (chicken/rooster combs). Each injection delivers 6 mL directly into the knee joint and is intended to provide up to 6 months of pain relief from a single office visit.

First approved by the FDA in 2009 (building on the earlier 3-injection Synvisc approved in 1997), Synvisc-One has one of the longest clinical track records in the single-injection category and remains among the most frequently administered viscosupplementation products in the U.S.

Several factors drive its cost:

Single injection vs. series: One visit vs. 3–5 visits for brands like Euflexxa or Hyalgan — but each visit carries its own copay and office fee
Avian sourcing: Hylan G-F 20 is derived from rooster combs, a traditional manufacturing process with an established safety profile
High molecular weight: The cross-linked hylan formula is engineered for durability in the joint space, which contributes to its up-to-6-month relief window
Allergy consideration: Because Synvisc-One is avian-derived, patients with allergies to birds, poultry, eggs, or feathers cannot use it and must choose a non-avian brand — Durolane or Monovisc are the non-avian single-injection options covered by Medicare

Synvisc-One Cost Without Insurance (Self-Pay)

Self-Pay Price Ranges for Synvisc-One (2026)

Cost Component	Range
Synvisc-One (clinic buy-and-bill, medication only)	$600–$1,200
Retail pharmacy list price	~$1,639–$1,745 per syringe
With SingleCare discount at pharmacy	~$1,344–$1,414
Office visit fee	$50–$200
Imaging guidance (if billed separately)	$100–$300
Total self-pay range	$750–$2,000+

Retail pharmacy prices per SingleCare (Walgreens: ~$1,639; Kroger: ~$1,643). Clinic/buy-and-bill pricing reflects typical provider self-pay rates. Source: SingleCare, GoodRx.

Why Prices Vary So Much

Synvisc-One pricing varies significantly based on how and where the injection is delivered:

Buy-and-bill vs. retail pharmacy: When a clinic purchases Synvisc-One directly from a wholesaler and administers it in-office, you pay the clinic’s self-pay rate — typically $600–$1,200 for the medication, well below the retail pharmacy price. Most insured patients experience buy-and-bill pricing without knowing it
Provider markup: Clinics set their own self-pay rates after buying at wholesale. Office-based practices typically charge less than hospital outpatient departments
Geographic location: Urban markets and high cost-of-living areas generally charge more
Discount cards at pharmacy: Programs like SingleCare or GoodRx apply at retail pharmacies, not at the clinic — ask in advance whether your provider will accept a discount card at time of service
Bundled procedure pricing: MDsave lists bundled in-office Synvisc injection prices from $260 to $1,796 depending on region and setting — the low end reflects aggressive cash pricing in certain markets (MDsave)

Tip: Call providers and ask for their “self-pay price” for a Synvisc-One injection — many offer discounted cash rates. Also ask whether imaging guidance (ultrasound or fluoroscopy) is included in the quoted price or billed separately, since that can add $100–$300 to your total.

Synvisc-One Cost With Medicare Part B

Medicare Coverage for Synvisc-One

Coverage status: Yes — Medicare Part B covers Synvisc-One (J7325)

Typical patient cost with Medicare:

Annual Part B deductible: $257 (2025; verify current year)
After deductible: You pay 20% coinsurance of the Medicare-approved amount
Medicare pays 80% of the approved amount

Estimated patient out-of-pocket (deductible already met):

Medication coinsurance (20% of $382 approved): **$76**
Administration fee 20% coinsurance (CPT 20610, $89 approved): **$18**
Total without imaging: ~$94–$120 per injection
With ultrasound imaging guidance: ~$120–$200

How Medicare Bills Synvisc-One

Medicare uses HCPCS code J7325 (Hyaluronan or derivative, Synvisc or Synvisc-One, for intra-articular injection, 1 mg) to reimburse Synvisc-One. Each Synvisc-One syringe contains 48 mg of hylan G-F 20, so providers bill 48 units of J7325 per injection.

The Medicare ASP (Average Sales Price) payment limit for J7325 is approximately $7.95 per mg as of Q4 2025, updated quarterly (CMS ASP Pricing Files). This means:

Total Medicare allowable for the medication: 48 mg × $7.95 = ~$382
Medicare pays 80% of that: ~$305
Your 20% coinsurance on the medication: ~$76

The injection administration is billed separately under CPT 20610 (aspiration and/or injection, major joint, without ultrasound) or CPT 20611 (with ultrasound guidance). Your 20% share of the administration fee adds approximately $15–$30, bringing the typical total patient cost to $90–$200 per injection depending on whether imaging is used and your provider’s billed amounts.

Actual costs vary by region, provider type, and whether you have a Medigap supplement. Under CMS Part B drug payment rules, Medicare reimburses J7325 at ASP + 6%, and the patient or secondary insurer is responsible for the remaining 20% (see Sanofi’s Synvisc-One HCP Medicare page for brand-specific billing guidance).

Medicare Coverage Requirements

Medicare requires documentation that:

You have a confirmed diagnosis of knee osteoarthritis

Conservative treatments have been tried without sufficient relief (physical therapy, NSAIDs, weight management)

Repeat treatments are at least 6 months apart

The injection is administered by a qualified, Medicare-enrolled provider

Medicare Advantage Plans

If you have a Medicare Advantage (Part C) plan, Synvisc-One coverage may differ from Original Medicare. Some Medicare Advantage plans require prior authorization, preferred provider networks, or step therapy requirements that Original Medicare does not impose. Always verify coverage with your specific plan before scheduling — and confirm prior authorization in writing if required, to avoid a retroactive claim denial.

Synvisc-One Cost With Private Insurance

Most commercial insurance plans cover Synvisc-One for knee osteoarthritis when medical necessity criteria are met, similar to Medicare requirements.

Typical private insurance process:

Prior authorization is almost always required — your provider’s office submits this on your behalf
Step therapy may require documented failure of conservative treatments (physical therapy, oral NSAIDs, corticosteroid injections) before viscosupplementation is approved
Copay or coinsurance: Varies by plan — typically $50–$200 per injection
Deductible: If not yet met, you pay the full allowed amount until the deductible is reached
Specialty drug tier: Some plans classify viscosupplementation under a specialty tier with higher cost-sharing; confirm your plan’s tier assignment before scheduling

Tip: Have your provider’s office call to verify coverage and obtain prior authorization before your appointment. A reputable clinic handles this verification proactively so you have no surprise bills.

Synvisc-One vs. Other Single-Injection Brands: Cost Comparison

Synvisc-One is one of four FDA-approved single-injection hyaluronic acid products. Understanding how its cost compares to alternatives — especially if you have an avian allergy — helps you have an informed conversation with your doctor.

Brand	Source	Self-Pay Estimate	Medicare Coverage	Allergy-Safe
Synvisc-One	Avian (chicken/rooster comb)	$600–$1,745	Yes (J7325)	No — avian-derived
Durolane	Non-animal (bacterial)	$300–$1,465	Yes (J7318)	Yes — bird/egg safe
Gel-One	Avian (rooster comb)	$400–$900	Yes (J7326)	No — avian-derived
Monovisc	Non-animal	$500–$1,000	Yes (J7327)	Yes — bird/egg safe

Avian allergy warning: Synvisc-One and Gel-One are derived from chicken/rooster combs. If you have any allergy to birds, poultry, eggs, or feathers, you must use a non-avian alternative. Durolane (J7318) and Monovisc (J7327) are the non-avian single-injection options covered by Medicare.

All four brands are covered by Medicare at broadly comparable payment levels. If your primary concern is cost, ask your provider which brand they have available at the most favorable pricing — and verify your allergy status before choosing an avian-derived product.

Synvisc-One vs. Multi-Injection Series: True Cost Comparison

Synvisc-One may appear more expensive per dose than a single injection in a multi-injection series, but the total cost often looks different when you count all visits.

	Synvisc-One (Single)	Synvisc (3 injections)	Euflexxa (3 injections)	Hyalgan (3–5 injections)
Injections needed	1	3	3	3–5
Office visits	1	3	3	3–5
Medication cost (self-pay)	$600–$1,745	$500–$1,200 total	$300–$900 total	$200–$800 total
Office visit copays	1×	3×	3×	3–5×
Time commitment	1 visit	3 weeks	3 weeks	3–5 weeks
Work/travel disruption	Minimal	Moderate	Moderate	Moderate–High

The hidden cost of series injections is time and visit copays. For Medicare patients with a $20 copay per visit, Synvisc-One saves $40 compared to a 3-injection series and up to $80 compared to a 5-injection Hyalgan course in visit copays alone — which partially offsets any difference in medication cost.

Hidden Costs to Budget For

When planning for Synvisc-One, account for these additional expenses beyond the injection itself:

Frequently Overlooked Costs

Office/consultation visit fee: $50–$200 (may be billed separately from the injection fee — ask upfront)

Imaging guidance: $100–$300 if billed separately — ultrasound guidance (CPT 20611 vs. 20610) improves injection accuracy and is increasingly standard practice. Medicare covers imaging guidance when medically indicated; confirm with your provider whether it’s included.

Pre-injection X-ray: If not already done, you may need knee X-rays to confirm the osteoarthritis diagnosis ($100–$300 without insurance)

Follow-up visit: Some providers schedule a follow-up 4–6 weeks post-injection to assess your response — this visit carries its own copay or office fee

Facility fees: Hospital outpatient departments charge a facility fee (often $200–$500+) on top of the injection fee. Office-based clinics typically do not charge facility fees, making them significantly less expensive for both self-pay and Medicare patients

How to Reduce Your Out-of-Pocket Costs

For Medicare Patients

Use a Medigap supplement: A Medigap (supplemental) policy covers most or all of the 20% coinsurance, potentially reducing your cost to near $0 for the medication and administration

Time your treatment: If you’ve already met your Part B deductible for the year, schedule before December 31 to avoid restarting the deductible clock in January

Choose office-based providers: Hospital outpatient departments charge facility fees that significantly increase your total Medicare coinsurance — office-based clinics are typically much less expensive

Confirm prior auth if on Medicare Advantage: Original Medicare generally does not require prior authorization for Synvisc-One, but Medicare Advantage plans often do — confirm before your visit to prevent a claim denial

For Self-Pay Patients

Use a discount card at the pharmacy: SingleCare reduces retail pharmacy pricing from ~$1,640 to approximately $1,344 (SingleCare); GoodRx offers similar savings (GoodRx)

Ask about clinic self-pay rates: Many practices offer significantly reduced cash rates for uninsured patients. Clinic buy-and-bill prices often run $600–$1,000 — well below the $1,600+ retail pharmacy price

Check MDsave for bundled pricing: MDsave lists in-office Synvisc injection bundles starting at $260 in some markets, with the procedure fee included — availability varies by region (MDsave)

Check Sanofi patient support: Contact Sanofi (Synvisc-One’s manufacturer) directly to ask about any available patient assistance programs or copay support options

Consider alternative brands: If cost is a barrier, multi-injection series brands like Hyalgan or Supartz FX may have lower per-dose medication costs while providing similar relief — though you’ll pay more office visit copays over the course of treatment

Frequently Asked Questions

Does Medicare cover Synvisc-One injections?

Yes. Medicare Part B covers Synvisc-One (billed as HCPCS code J7325) for knee osteoarthritis when medically necessary. After meeting the annual Part B deductible ($257 in 2025; verify current year), you pay 20% coinsurance. Based on the Q4 2025 ASP payment limit of ~$7.95 per mg, the total Medicare-approved amount for one 48 mg Synvisc-One injection is approximately $382 — your coinsurance on the medication is roughly $76. Including the administration fee (CPT 20610/20611), total patient cost is typically $94–$200 per injection depending on imaging (CMS ASP Pricing Files).

How much does Synvisc-One cost without insurance?

At a clinic using buy-and-bill pricing, Synvisc-One typically costs $600–$1,200 for the medication, with total procedure costs of $750–$1,700+ when office visit and imaging fees are added. At a retail pharmacy, the list price is approximately $1,639–$1,745 per syringe; with a SingleCare discount card, you can pay approximately $1,344 (SingleCare). MDsave lists bundled in-office procedure prices starting at $260 in some markets (MDsave).

Is Synvisc-One safe for patients with bird or egg allergies?

No. Synvisc-One is derived from avian sources (chicken/rooster combs) and is contraindicated in patients with allergies to birds, poultry, eggs, or feathers. If you have any such allergy, inform your provider before scheduling. The non-avian single-injection alternatives covered by Medicare are Durolane (HCPCS J7318) and Monovisc (J7327).

How does Synvisc-One compare in cost to other single-injection brands?

All four FDA-approved single-injection brands (Synvisc-One, Durolane, Gel-One, Monovisc) are covered by Medicare at broadly comparable payment levels. Self-pay retail pricing varies: Durolane lists at ~$300–$1,465, Monovisc at ~$500–$1,000, Gel-One at ~$400–$900, and Synvisc-One at ~$600–$1,745. The most important non-cost distinction: Synvisc-One and Gel-One are avian-derived; Durolane and Monovisc are not.

How often can I receive Synvisc-One, and what does that cost annually?

Medicare allows repeat Synvisc-One treatment every 6 months when the previous course was effective. Annual cost for two courses with Medicare (deductible already met) is typically $188–$400 in total patient coinsurance. Self-pay patients paying clinic rates would spend approximately $1,200–$2,400 annually for twice-yearly treatment, or $2,688–$3,490 at retail pharmacy prices before any discount.

What CPT and HCPCS codes are used for Synvisc-One billing?

Synvisc-One is billed using HCPCS code J7325 (Hyaluronan or derivative, Synvisc or Synvisc-One, for intra-articular injection, per 1 mg). One 6 mL / 48 mg syringe equals 48 units of J7325. The injection procedure itself is billed under CPT 20610 (arthrocentesis, aspiration and/or injection, major joint, without ultrasound guidance) or CPT 20611 (with ultrasound guidance). Both J7325 and CPT 20610/20611 are reimbursable under Medicare Part B when medical necessity criteria are met.

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Last updated: March 2026. Pricing information reflects current market data and is subject to change. Medicare ASP payment rates are updated quarterly by CMS. Always verify costs with your specific provider and insurance plan.

Medical Disclaimer: This article is for educational purposes only. Consult your healthcare provider to determine if Synvisc-One is appropriate for your condition and to verify current coverage with your insurance plan.