Pioneer vs. Premium
Hyalgan was first to market (1997) with unmatched long-term safety data. Orthovisc came later but offers higher molecular weight that closely matches healthy synovial fluid.
Side-by-Side Comparison
| Factor | Hyalgan | Orthovisc |
|---|---|---|
| FDA approval | 1997 | 2004 |
| Molecular weight | Low-medium | High |
| Injections | 3-5 weekly | 3-4 weekly |
| Self-pay | $500-$900 | $600-$900 |
| Duration | 3-6 months | 3-12 months |
| Manufacturer | Fidia Pharma | DePuy Synthes (J&J) |
Key Differences
Hyalgan Advantages
- Longest track record - 25+ years of real-world use
- Often lowest cost - Most affordable option
- Flexible protocol - 3-5 injections based on response
Orthovisc Advantages
- Higher molecular weight - Closer to natural synovial fluid
- Potentially longer duration - Some patients report 12 months
- J&J quality - Major orthopedic company backing
Making Your Decision
Choose Hyalgan if:
- Cost is a primary concern
- You value longest safety track record
- You prefer flexible dosing options
Choose Orthovisc if:
- You want higher molecular weight
- Longer duration matters
- Your insurance prefers J&J products
Allergy Note
Both are avian-derived. If you have bird/egg allergies, consider Euflexxa as a non-avian alternative.
The Bottom Line
Hyalgan: The proven original at the lowest cost. Orthovisc: Higher MW with potentially longer relief. Both work well—let cost and duration expectations guide your choice.
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