Two OG Treatments Go Head-to-Head
Hyalgan (FDA 1997) and Supartz (FDA 2001) are both pioneers in the HA injection space. Together they have over 40 years of combined real-world safety data.
Side-by-Side Comparison
| Factor | Hyalgan | Supartz |
|---|---|---|
| FDA approval | 1997 | 2001 |
| Injections | 3-5 (flexible) | 5 weekly |
| Molecular weight | Low-medium | Medium |
| Self-pay | $500-$900 | $600-$1,000 |
| Source | Avian | Avian |
| Duration | 3-6 months | Up to 6 months |
Key Differences
Hyalgan Advantages
- First in US - Longest track record
- Flexible protocol - 3-5 injections based on response
- Often lowest cost - Most affordable HA option
Supartz Advantages
- Slightly higher MW - May provide longer cushioning
- Consistent protocol - Always 5 injections
- Supartz FX variant - 3-injection option available
Allergy Note
Both are avian-derived. If you have bird/egg allergies, consider Euflexxa as a non-avian multi-injection alternative.
Making Your Decision
Choose Hyalgan if:
- You want the longest safety track record
- Cost is a primary concern
- You prefer flexible dosing options
Choose Supartz if:
- You want slightly higher molecular weight
- You prefer a set 5-injection protocol
- Your insurance prefers it
The Bottom Line
Both are proven, affordable multi-injection options. Your provider’s experience and insurance coverage should guide the choice—clinically, they’re very similar.
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