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Treatment Comparison

Supartz vs Synvisc

Compare Supartz (5 weekly) and Synvisc (3 weekly). Key differences in injection count, molecular weight, and protocols.

Side-by-Side Comparison

Injections Needed

Supartz 5 weekly
Synvisc 3 weekly

Molecular Weight

Supartz Medium (620-1,170 kDa)
Synvisc Very high (6M Da)

Office Visits

Supartz 5
Synvisc 3

FDA Approval

Supartz 2001
Synvisc 1997

Self-Pay Cost

Supartz $600-$1,000
Synvisc $700-$1,000

Duration

Supartz Up to 6 months
Synvisc Up to 6 months

Source

Supartz Avian
Synvisc Avian

Medicare Coverage

Supartz Yes
Synvisc Yes

It Depends on Your Situation

Supartz requires 5 injections with medium MW. Synvisc needs only 3 with very high MW. Both are effective avian-derived treatments.

Best for: Supartz for extended protocol; Synvisc for fewer visits and higher MW.

5 Visits vs. 3 Visits

Supartz uses a 5-injection protocol. Synvisc achieves results with just 3 injections but at higher molecular weight. Which approach works better?


Side-by-Side Comparison

FactorSupartzSynvisc
Injections5 weekly3 weekly
Molecular weightMediumVery high (6M Da)
Office visits53
Self-pay$600-$1,000$700-$1,000
FDA approval20011997
DurationUp to 6 monthsUp to 6 months

Key Differences

Supartz Advantages

  • Extended delivery - More gradual treatment over 5 weeks
  • Often lower cost - Especially vs. Synvisc-One
  • Supartz FX option - 3-injection variant available

Synvisc Advantages

  • Fewer visits - 3 vs. 5 appointments (40% less)
  • Highest molecular weight - Maximum cushioning potential
  • Longer track record - FDA approved 4 years earlier
  • Single-shot option - Can upgrade to Synvisc-One

Making Your Decision

Choose Supartz if:

  • You prefer extended 5-week delivery
  • Cost is a primary concern
  • Your provider has strong Supartz experience

Choose Synvisc if:

  • Fewer appointments is important
  • You want highest molecular weight
  • You might later try Synvisc-One

The Bottom Line

Synvisc requires 40% fewer visits with higher MW. Supartz offers more gradual delivery over 5 weeks. Both provide similar duration of relief—choose based on scheduling and MW preferences.

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