Two High-MW Powerhouses
Synvisc and Orthovisc are both premium, high molecular weight multi-injection treatments. They come from different pharmaceutical giants with different formulation approaches.
Side-by-Side Comparison
| Factor | Synvisc | Orthovisc |
|---|---|---|
| Molecular weight | Very high (6M Da) | High (1-2.9M Da) |
| Manufacturer | Sanofi | DePuy Synthes (J&J) |
| Injections | 3 weekly | 3-4 weekly |
| Self-pay | $700-$1,000 | $600-$900 |
| Duration | Up to 6 months | 3-12 months (varies) |
| FDA approval | 1997 | 2004 |
Key Differences
Synvisc Advantages
- Highest molecular weight - 6 million Daltons
- Longest track record - FDA approved since 1997
- Cross-linked polymer - Enhanced viscosity
Orthovisc Advantages
- Often lower cost - $100-200 cheaper
- Potentially longer duration - Some report 12 months
- J&J quality - Major orthopedic company backing
- Leads to Monovisc - Can transition to single-shot version
Making Your Decision
Choose Synvisc if:
- You want the highest MW available
- Longest track record matters
- Your provider has Synvisc experience
Choose Orthovisc if:
- Cost is a consideration
- You might later try Monovisc (same company)
- Your insurance prefers J&J products
The Bottom Line
Both are excellent high-MW options. Synvisc offers the highest MW and longest history. Orthovisc is often cheaper with J&J backing. Clinical outcomes are similar—let cost and provider experience guide your choice.
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