Synvisc-One Injection Cost: What You'll Pay in 2026 (With and Without Insurance)
Synvisc-One self-pay costs $600–$1,200 per injection. With Medicare Part B, patients pay roughly $100–$250. Complete 2026 guide to Synvisc-One pricing, coverage, and cost-saving options.
By Joint Pain Authority Team
Key Takeaways
- Synvisc-One self-pay cost typically ranges from $600 to $1,200 per injection at most providers
- With Medicare Part B, patients pay approximately $100–$250 (20% coinsurance after the annual deductible)
- Synvisc-One is billed under HCPCS code J7321 (hylan G-F 20, 1 mg per unit)
- Unlike Durolane and Euflexxa, Synvisc-One is avian-derived (rooster comb) — patients with bird or egg allergies should choose a non-avian brand
- As a single-injection product, Synvisc-One requires only one office visit vs. 3–5 visits for series brands
What Is Synvisc-One?
Synvisc-One is a single-injection hyaluronic acid treatment for knee osteoarthritis, manufactured by Sanofi. It contains hylan G-F 20, a cross-linked form of hyaluronan derived from chicken combs, delivered as a single 6 mL injection for up to 6 months of relief.
First approved by the FDA in 2009 (following the earlier 3-injection Synvisc approved in 1997), Synvisc-One is one of the most widely prescribed gel injection products in the United States and has one of the longest clinical track records in the single-injection category.
Synvisc-One Cost Without Insurance (Self-Pay)
Self-Pay Price Range for Synvisc-One (2026)
| Cost Component | Range |
|---|---|
| Synvisc-One injection (medication) | $600–$1,200 |
| Office visit fee | $50–$200 |
| Imaging guidance (recommended) | $100–$300 |
| Total estimated self-pay | $750–$1,700 |
Prices vary by provider, location, and whether imaging guidance is included.
Ways to reduce self-pay cost:
- Ask providers for their cash/self-pay price — many offer discounts off list price
- Use prescription discount programs to check available savings
- Compare pricing between office-based clinics vs. hospital outpatient departments (hospitals typically charge more due to facility fees)
Synvisc-One Cost With Medicare Part B
Medicare Coverage for Synvisc-One
Coverage status: Yes — Medicare Part B covers Synvisc-One (J7321)
Billing code: J7321 (hylan G-F 20, 1 mg per unit; Synvisc-One contains 48 mg = 48 units)
Typical patient cost:
- After deductible is met: ~$100–$250 (20% of Medicare-approved amount)
- If deductible not yet met: Annual Part B deductible ($257 in 2025) + 20% of remainder
Medicare Coverage Requirements
Medicare requires:
- Confirmed diagnosis of knee osteoarthritis
- Documentation of conservative treatment failure (physical therapy, weight management, NSAIDs)
- Minimum 6 months between repeat treatment courses
Synvisc-One vs. Other Single-Injection Brands
| Brand | Source | Self-Pay Range | Medicare (J-Code) | Bird Allergy Safe |
|---|---|---|---|---|
| Synvisc-One | Avian | $600–$1,200 | Yes (J7321) | No |
| Durolane | Non-animal | $300–$1,465 | Yes (J7318) | Yes |
| Gel-One | Avian | $400–$900 | Yes (J7320) | No |
| Monovisc | Non-animal | $500–$1,000 | Yes (J7322) | Yes |
Important: Synvisc-One is derived from rooster combs. If you have allergies to birds, poultry, eggs, or feathers, ask your doctor about Durolane or Monovisc instead.
Frequently Asked Questions
Does Medicare cover Synvisc-One injections?
Yes. Medicare Part B covers Synvisc-One for knee osteoarthritis when medically necessary, billed as HCPCS code J7321. Patients typically pay 20% coinsurance after meeting their Part B deductible. Prior authorization is generally not required for Medicare, but documentation of medical necessity is.
How much is Synvisc-One without insurance?
Without insurance, Synvisc-One typically costs $600–$1,200 for the medication, plus $50–$200 for the office visit and $100–$300 for imaging guidance if billed separately. Total out-of-pocket costs range from approximately $750–$1,700 depending on provider and location.
How often can I get Synvisc-One?
Medicare allows repeat Synvisc-One treatment every 6 months when the previous course was effective. Some patients receive treatment annually. Your provider will assess your response before recommending repeat treatment.
Is Synvisc-One covered by private insurance?
Most commercial insurance plans cover Synvisc-One for knee osteoarthritis when medically necessary, typically with prior authorization and step therapy requirements. Check with your specific plan for copay amounts and coverage details.
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Related Resources
- Durolane Injection Cost Guide: 2026 Pricing
- Knee Gel Injection Cost Guide: All Brands Compared
- Single Injection vs. Series: Which Is Right for You?
- HA Brands Guide 2026: All 8 FDA-Approved Options
- Medicare Part B Coverage for Knee Injections
- Bird Allergy and Gel Injections: Safe Alternatives
Last updated: March 2026. Verify current pricing and coverage with your provider and insurance plan.
Medical Disclaimer: This article is for educational purposes only. Consult your healthcare provider to determine if Synvisc-One is appropriate for your condition.
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