Single-Injection Showdown: Orthopedic Giant vs. Pharma Leader
Both Gel-One and Synvisc-One deliver complete HA treatment in a single injection. They’re both avian-derived. But they come from very different companies with different formulations.
Side-by-Side Comparison
| Factor | Gel-One | Synvisc-One |
|---|---|---|
| Manufacturer | Zimmer Biomet | Sanofi |
| Injections needed | 1 | 1 |
| Volume | 3 mL | 6 mL |
| Molecular weight | High (500-730 kDa) | Very high (6M Da) |
| Cross-linked | Yes | Yes |
| Source | Avian | Avian |
| FDA approval | 2011 | 2009 |
| Duration of relief | 4-6 months | Up to 6 months |
| Self-pay cost | $700-$1,000 | $800-$1,200 |
Gel-One: From the Joint Replacement Experts
What It Is
Gel-One comes from Zimmer Biomet, a global leader in orthopedic implants and joint replacement. They know joints—and they’ve created a single-injection HA with a smaller volume footprint.
Key Advantages
Considerations
Synvisc-One: The Original Single-Shot
What It Is
Synvisc-One from Sanofi was the first single-injection HA to hit the market. It contains hylan G-F 20—a very high molecular weight, cross-linked hyaluronic acid.
Key Advantages
Considerations
The Volume Question
| Aspect | Gel-One (3 mL) | Synvisc-One (6 mL) |
|---|---|---|
| Post-injection swelling | Less likely | More common |
| Immediate discomfort | Less | More |
| Total HA delivered | Less | More |
| Theoretical cushioning | Lower | Higher |
Clinical reality: Despite the volume difference, patient outcomes are similar. The extra volume in Synvisc-One doesn’t necessarily translate to better or longer relief.
Allergy Warning
Both Require Allergy Screening
Neither Gel-One nor Synvisc-One is safe for:
- Egg allergies
- Chicken allergies
- Feather allergies
- Any poultry sensitivity
If you have avian allergies, consider Durolane (single-injection, non-avian) instead.
Cost Comparison
| Factor | Gel-One | Synvisc-One |
|---|---|---|
| Self-pay | $700-$1,000 | $800-$1,200 |
| Medicare typical | $100-$300 | $100-$350 |
| Relative position | Often lower | Often higher |
Making Your Decision
Choose Gel-One if:
- You prefer smaller injection volume
- Cost is a significant factor
- You’ve used Zimmer Biomet products before
- Your provider recommends it
Choose Synvisc-One if:
- You want the highest molecular weight option
- You prefer the most established product
- Your provider has extensive Synvisc experience
- Insurance covers both equally
The Bottom Line
Both Deliver Single-Injection Convenience
Gel-One and Synvisc-One are both effective single-injection treatments. The differences:
- Gel-One: Smaller volume, lower cost, from the joint replacement experts
- Synvisc-One: Higher molecular weight, more data, the original single-shot
For most patients, either works well. Choose based on cost, volume preference, and provider recommendation.
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Questions? Browse our guides:
How to Choose a ProviderRelated Resources
- Gel-One Complete Guide
- Synvisc-One Complete Guide
- All Single-Injection Options
- Medicare Coverage for Knee Injections
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