The Pioneer vs. The Modern Alternative
Hyalgan was the first HA injection approved in the United States (1997), giving it nearly three decades of real-world safety data. Euflexxa arrived later but offers something Hyalgan can’t: safety for patients with bird allergies.
Side-by-Side Comparison
| Factor | Hyalgan | Euflexxa |
|---|---|---|
| FDA approval | 1997 (first in US) | 2004 |
| Source | Avian (rooster comb) | Bacterial fermentation |
| Bird allergy safe | No | Yes |
| Injections | 3-5 weekly | 3 weekly |
| Molecular weight | Low-medium | Medium |
| Self-pay | $500-$900 | $600-$900 |
| Duration | 3-6 months | 6+ months |
Hyalgan: The Original
Key Advantages
Considerations
Euflexxa: The Modern Non-Avian
Key Advantages
Considerations
Making Your Decision
Choose Hyalgan if:
- You have no bird/egg allergies
- You value the longest safety track record
- Cost is a primary concern
- Your provider has extensive Hyalgan experience
Choose Euflexxa if:
- You have any avian allergies
- You prefer non-animal products
- You want a predictable 3-injection protocol
- Duration of relief is a priority
The Bottom Line
Hyalgan is the tried-and-true original with unmatched long-term safety data. Euflexxa is the modern alternative that opens HA treatment to allergy patients. Both work—choose based on your allergy status and cost preferences.
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