Multi-Injection Head-to-Head
Orthovisc and Euflexxa are both multi-injection HA treatments requiring 3-4 weekly visits. They’re similarly priced but have one crucial difference: source material.
Side-by-Side Comparison
| Factor | Orthovisc | Euflexxa |
|---|---|---|
| Source | Avian (rooster comb) | Bacterial fermentation |
| Bird allergy safe | No | Yes |
| Injections | 3-4 weekly | 3 weekly |
| Molecular weight | High (1-2.9M Da) | Medium (2.4-3.6M Da) |
| Self-pay | $600-$900 | $600-$900 |
| Duration | 3-12 months (varies) | 6+ months |
| Manufacturer | DePuy Synthes (J&J) | Ferring Pharmaceuticals |
Orthovisc: Mimicking Natural Fluid
Key Advantages
High molecular weight - Closely matches healthy synovial fluid
Longer potential duration - Some patients report 12 months relief
J&J quality - From a trusted orthopedic company
Considerations
Not for avian allergies - Rooster comb derived
Euflexxa: The Allergy-Safe Choice
Key Advantages
Bird allergy safe - No animal-derived ingredients
Consistent 3 injections - Predictable treatment schedule
Insurance-preferred - Often on formulary lists
Considerations
Lower molecular weight - May not match natural fluid as closely
Making Your Decision
Choose Orthovisc if:
- You have no bird/egg allergies
- You want the highest MW multi-injection option
- Your insurance prefers J&J products
- Your provider has good Orthovisc experience
Choose Euflexxa if:
- You have any avian allergies
- You prefer non-animal products
- Your insurance lists it as preferred
- You want exactly 3 injections (not 3-4)
The Bottom Line
Both are effective multi-injection treatments at similar prices. Allergies are the deciding factor—Euflexxa for avian sensitivities, Orthovisc for everyone else.
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