Same Company, Different Approaches
Orthovisc and Monovisc both come from DePuy Synthes (Johnson & Johnson’s orthopedic division). They use the same source material and similar molecular weight—the difference is how the treatment is delivered.
Side-by-Side Comparison
| Factor | Orthovisc | Monovisc |
|---|---|---|
| Manufacturer | DePuy Synthes (J&J) | DePuy Synthes (J&J) |
| Injections | 3-4 weekly | 1 single |
| Volume per injection | 2 mL | 4 mL |
| Total volume | 6-8 mL | 4 mL |
| Self-pay | $600-$900 | $700-$1,100 |
| Duration | 3-12 months | Up to 6 months |
| Source | Avian | Avian |
The Delivery Question
Orthovisc: Gradual Approach
- Multiple smaller injections spread over 3-4 weeks
- Treatment builds up over time
- Lower volume per visit (2 mL each)
- Longer reported duration for some patients (up to 12 months)
Monovisc: One-and-Done
- Single appointment for complete treatment
- Immediate full dose delivery
- Single copay for treatment
- Convenience for busy schedules
Cost Analysis
| Factor | Orthovisc | Monovisc |
|---|---|---|
| Self-pay | $600-$900 | $700-$1,100 |
| Office visits | 3-4 | 1 |
| Copays | 3-4 × copay | 1 × copay |
| Time investment | Higher | Lower |
Making Your Decision
Choose Orthovisc if:
- You prefer gradual delivery
- You can attend 3-4 weekly appointments
- Cost is a primary concern
- You’ve had success with multi-injection protocols
Choose Monovisc if:
- Convenience is your priority
- Scheduling multiple visits is difficult
- You prefer single-visit treatment
- You’re willing to pay slightly more
Allergy Note
Both products are avian-derived and contraindicated for bird/egg allergies. If you have allergies, consider Durolane (single) or Euflexxa (multi-injection) as non-avian alternatives.
The Bottom Line
From the same trusted manufacturer, Orthovisc and Monovisc offer different treatment experiences:
- Orthovisc: More visits, potentially longer relief, lower cost
- Monovisc: One visit, ultimate convenience, slightly higher cost
Both are effective. Your schedule and preferences should guide the choice.
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