Single-Injection Showdown
When your doctor recommends a single-injection hyaluronic acid treatment for knee osteoarthritis, Synvisc-One and Durolane are two leading options. Both deliver the full treatment in one visit—but they have one critical difference.
The key question: Do you have bird or egg allergies?
Side-by-Side Comparison
| Factor | Synvisc-One | Durolane |
|---|---|---|
| Injections needed | 1 | 1 |
| Source | Avian (rooster comb) | Non-animal (NASHA) |
| Bird allergy safe | No | Yes |
| Volume | 6 mL | 3 mL |
| Molecular weight | Very high (6M Da) | High (cross-linked) |
| Duration of relief | Up to 6 months | Up to 6 months |
| Self-pay cost | $800-$1,200 | $900-$1,300 |
| With insurance | $100-$350 | $150-$400 |
| Manufacturer | Sanofi | Bioventus |
Synvisc-One: The Established Leader
What It Is
Synvisc-One contains hylan G-F 20, a high molecular weight hyaluronic acid derived from rooster combs. It’s one of the most widely used and studied single-injection HA products.
Advantages
Considerations
Best For
- Patients with no avian allergies
- Those seeking the most established single-injection option
- Price-conscious patients (often lower cost)
- Anyone who’s responded well to original Synvisc
Durolane: The Allergy-Safe Alternative
What It Is
Durolane uses NASHA (Non-Animal Stabilized Hyaluronic Acid) technology—hyaluronic acid produced through bacterial fermentation with zero animal products.
Advantages
Considerations
Best For
- Patients with bird or egg allergies
- Those preferring non-animal products (ethical/religious reasons)
- Patients who’ve had reactions to avian-derived HA
- Anyone who prefers smaller injection volumes
The Allergy Factor
Critical: Check Your Allergies First
If you’re allergic to:
- Eggs
- Chicken
- Feathers or down
- Any poultry products
Synvisc-One is contraindicated. Durolane is your only single-injection option.
Even if you’ve never been formally tested, tell your doctor about any reactions to poultry or eggs before choosing a product.
Cost Comparison
| Factor | Synvisc-One | Durolane |
|---|---|---|
| Self-pay | $800-$1,200 | $900-$1,300 |
| Medicare (typical) | $100-$350 | $150-$400 |
| Private insurance | Similar | Similar |
| Office visits | 1 | 1 |
Note: Durolane’s slightly higher price often reflects its unique non-avian positioning. Some insurance plans may prefer one over the other—always check your specific coverage.
Clinical Effectiveness
Research shows both products provide similar outcomes:
- Pain reduction: Comparable in clinical trials
- Duration of relief: Both approximately 6 months
- Function improvement: Similar gains in mobility
- Repeat treatment: Both can be repeated when effects wear off
The bottom line: Neither has proven superiority in head-to-head trials. Choose based on your allergy status, price sensitivity, and provider recommendations.
Making Your Decision
Choose Synvisc-One if:
- You have no bird/egg allergies
- Cost is a significant factor
- You want the most established single-injection product
- Your provider recommends it
Choose Durolane if:
- You have or might have bird/egg allergies
- You prefer non-animal products
- You’ve reacted to avian-derived HA before
- You prefer smaller injection volume
Questions to Ask Your Doctor
- Which product do you have the most experience with?
- Do I have any allergies that would rule out Synvisc-One?
- What does my insurance cover for each option?
- Have you seen different results with these products?
- Which would you recommend for my specific situation?
The Bottom Line
Both Are Excellent Single-Injection Options
Synvisc-One is the established choice for most patients—widely available, extensively studied, and often more affordable.
Durolane is the clear winner for patients with avian allergies—it’s the only single-injection option that’s completely bird-free.
If you have no allergies and cost matters, lean toward Synvisc-One. If you have any allergy concerns or prefer non-animal products, Durolane is your answer.
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- 3 Contact you to discuss your options
Questions? Browse our guides:
How to Choose a ProviderRelated Resources
- Synvisc-One Complete Guide
- Durolane Complete Guide
- All Single-Injection HA Options
- Medicare Coverage for Knee Injections
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