Same Formula, Different Delivery
Synvisc and Synvisc-One contain the identical hylan G-F 20 formula from Sanofi—the difference is purely in how it’s delivered. Both deliver 6 mL total.
Side-by-Side Comparison
| Factor | Synvisc | Synvisc-One |
|---|---|---|
| Formula | Hylan G-F 20 | Hylan G-F 20 |
| Total volume | 6 mL (2 mL × 3) | 6 mL (single) |
| Injections | 3 weekly | 1 |
| Office visits | 3 | 1 |
| Self-pay | $700-$1,000 | $800-$1,200 |
| FDA approval | 1997 | 2009 |
| Duration | Up to 6 months | Up to 6 months |
Key Differences
Synvisc (Original) Advantages
- Smaller per-visit volume - 2 mL vs. 6 mL
- Gradual buildup - Treatment delivered over 3 weeks
- Often lower total cost
- Longer track record - 12 years more experience
Synvisc-One Advantages
- Single visit - Complete in one appointment
- Single copay - One insurance billing
- Maximum convenience - No return visits needed
- Same effectiveness - Same total formula delivered
Which to Choose?
Choose Synvisc (original) if:
- You prefer smaller individual injections
- You want gradual delivery over time
- Cost is a consideration
- You can attend 3 weekly appointments
Choose Synvisc-One if:
- Convenience is your priority
- Scheduling multiple visits is difficult
- You want treatment done in one visit
- You prefer fewer copays
Allergy Note
Both are avian-derived. Neither is safe for patients with bird, egg, or feather allergies. Consider Euflexxa (3-injection) or Durolane (single) as non-avian alternatives.
The Bottom Line
Same formula, same effectiveness, different convenience. If you’ve had success with one, the other should work equally well. Choose based on your scheduling preferences and willingness to make multiple visits.
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