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Fibromyalgia

Comprehensive guide to fibromyalgia and joint pain. Learn how this chronic widespread pain condition differs from arthritis, its symptoms, risk factors, and evidence-based treatment options.

Medically Reviewed Content by Medical Review Team, MD

Reviewed Mar 6, 2026

Approximately 4 million US adults (2% of the adult population) affected
Most common in ages 30-80+ (most common in middle age)
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What is Fibromyalgia?

Fibromyalgia is a chronic pain condition that causes widespread musculoskeletal pain, fatigue, and tenderness throughout the body. Unlike osteoarthritis, which results from cartilage breakdown in specific joints, fibromyalgia involves how the brain and spinal cord process pain signals. This means the pain is real, but the underlying cause is different from joint damage.

An estimated 4 million American adults live with fibromyalgia, making it one of the most common chronic pain conditions. Women are affected far more often than men, and the condition is most frequently diagnosed between the ages of 30 and 60, though it can persist well into older age.

Many people with fibromyalgia also have osteoarthritis or other joint conditions, which can make diagnosis more challenging. Research published in the journal Arthritis & Rheumatology suggests that 20 to 30 percent of patients with rheumatic diseases such as osteoarthritis also meet the criteria for fibromyalgia.

How Fibromyalgia Differs from Osteoarthritis

Understanding the difference between fibromyalgia and osteoarthritis is important because the treatments are different.

Osteoarthritis:

  • Caused by physical wear and tear on joint cartilage
  • Pain is localized to specific joints
  • Visible changes on X-rays (joint space narrowing, bone spurs)
  • Responds well to joint injections and surgical repair

Fibromyalgia:

  • Caused by changes in how the nervous system processes pain
  • Pain is widespread across many body areas
  • No visible joint damage on imaging
  • Responds to medications targeting pain processing, exercise, and stress management

It is possible to have both conditions at the same time. If you have osteoarthritis in your knees or hips and also experience pain throughout your body, fatigue, and sleep problems, fibromyalgia may be a contributing factor.

Symptoms to Watch For

Core Symptoms

  • Widespread pain affecting both sides of the body, above and below the waist, lasting at least three months
  • Chronic fatigue that does not improve with rest
  • Cognitive difficulties often called “fibro fog,” including trouble with memory and concentration
  • Sleep disturbances such as waking unrefreshed despite sleeping a full night
  • Morning stiffness that can mimic arthritis
  • Joint tenderness without visible swelling or redness
  • Aching in multiple joints that shifts location over time
  • Sensitivity to pressure at specific tender points

Associated Symptoms

  • Headaches or migraines
  • Irritable bowel syndrome
  • Numbness or tingling in hands and feet
  • Sensitivity to temperature, noise, or bright lights
  • Anxiety or depression (affects 30 to 50 percent of patients)

Causes and Risk Factors

The exact cause of fibromyalgia is not fully understood, but current research points to a process called central sensitization. This means the brain and spinal cord amplify pain signals, causing pain that feels more intense than the actual stimulus would normally produce.

Factors That Increase Risk

  • Gender: Women account for up to 90 percent of fibromyalgia diagnoses
  • Age: Most commonly diagnosed between ages 30 and 60, but symptoms often persist into the 70s and 80s
  • Family history: Fibromyalgia tends to run in families, suggesting a genetic component
  • Existing conditions: Having osteoarthritis, rheumatoid arthritis, or lupus increases the risk
  • Physical trauma: Car accidents, surgery, or repetitive injuries can trigger onset
  • Emotional stress: Prolonged psychological stress is a known trigger
  • Obesity: Excess weight is associated with higher fibromyalgia severity

Diagnosis

There is no single blood test or imaging study that confirms fibromyalgia. Diagnosis is based on clinical evaluation.

Diagnostic Criteria

Current guidelines from the American College of Rheumatology require:

  • Widespread pain lasting at least three months
  • Symptoms not explained by another medical condition
  • Assessment of symptom severity using standardized questionnaires

Tests to Rule Out Other Conditions

Your doctor may order the following to exclude conditions that mimic fibromyalgia:

  • Blood tests: Complete blood count, thyroid function, vitamin D levels, inflammatory markers (ESR, CRP)
  • X-rays or MRI: To check for arthritis or other structural problems
  • Rheumatology evaluation: To rule out autoimmune conditions

Treatment Options

Fibromyalgia treatment works best when it combines multiple approaches. No single treatment addresses all symptoms.

Physical Therapy and Exercise

Regular physical activity is one of the most effective treatments for fibromyalgia. Research consistently shows that:

  • Low-impact aerobic exercise (walking, swimming, cycling) reduces pain and improves function
  • Strength training helps support joints and reduces fatigue
  • Stretching and flexibility work eases morning stiffness
  • Aquatic therapy is especially beneficial due to the support and warmth of water

A physical therapist can create a safe, gradual exercise program tailored to your current fitness level and pain tolerance.

Medications

Several medications are FDA-approved for fibromyalgia:

  • Duloxetine (Cymbalta): A serotonin-norepinephrine reuptake inhibitor (SNRI) that helps with pain and mood
  • Pregabalin (Lyrica): An anti-seizure medication that reduces nerve pain signals
  • Milnacipran (Savella): Another SNRI specifically approved for fibromyalgia pain

Over-the-counter pain relievers such as acetaminophen, ibuprofen, and naproxen may help with mild symptoms but are generally less effective for fibromyalgia than for osteoarthritis.

Complementary Approaches

  • Cognitive behavioral therapy (CBT) to develop coping strategies
  • Mindfulness meditation and stress reduction techniques
  • Acupuncture (some evidence of benefit)
  • Massage therapy for temporary pain relief
  • Tai chi and yoga combining gentle movement with relaxation

Sleep Management

Improving sleep quality is a critical part of treatment:

  • Maintain a consistent sleep schedule
  • Create a cool, dark, quiet sleeping environment
  • Avoid caffeine and screens before bedtime
  • Discuss sleep disorders like sleep apnea with your doctor

Living with Fibromyalgia

Fibromyalgia is a chronic condition, but many patients achieve significant improvement in their quality of life through consistent treatment. Key strategies include:

  • Pacing activities to avoid overdoing it on good days
  • Staying active with regular, gentle exercise
  • Managing stress through relaxation and support
  • Working with a care team that understands your condition
  • Tracking symptoms to identify patterns and triggers

Questions to Ask Your Healthcare Provider

  1. Could my joint pain be caused by fibromyalgia, osteoarthritis, or both?
  2. What tests can help determine the cause of my pain?
  3. Would physical therapy or aquatic therapy be appropriate for me?
  4. Are there medications that could help my specific symptoms?
  5. Should I see a rheumatologist for further evaluation?
  6. How can I tell if a new pain is fibromyalgia or a different joint problem?

Frequently Asked Questions

Is fibromyalgia a form of arthritis?

No. Fibromyalgia is not a form of arthritis because it does not cause inflammation or damage to the joints. However, it is often grouped with arthritis-related conditions because it causes joint and muscle pain. The Arthritis Foundation includes fibromyalgia as a related condition.

Can you have fibromyalgia and osteoarthritis at the same time?

Yes. Research suggests that 20 to 30 percent of people with osteoarthritis or rheumatoid arthritis also have fibromyalgia. Having both conditions can make pain management more complex and may require a combination of treatments targeting each condition.

Does fibromyalgia get worse with age?

Fibromyalgia symptoms can fluctuate over time. Some patients find symptoms improve with proper management, while others experience periods of increased pain (flares). Age-related conditions like osteoarthritis may add to overall pain levels in older adults.

Will joint injections help fibromyalgia pain?

Joint injections such as cortisone or hyaluronic acid are designed to treat joint-specific problems like osteoarthritis. They are generally not effective for fibromyalgia pain alone. However, if you have both fibromyalgia and osteoarthritis, injections may help the arthritic component of your pain.


This content is for educational purposes only and does not replace professional medical advice. If you are experiencing widespread pain, fatigue, or other symptoms described above, consult your healthcare provider for proper evaluation and diagnosis.

Typical Medicare out-of-pocket: $150–$300 per treatment

Most fibromyalgia treatments are covered by Medicare Part B

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