Compare All 15 FDA-Approved Gel Injection Brands

Not all gel shots are the same. Compare injection schedules, allergy safety, insurance coverage, and costs to find the right brand for your knee osteoarthritis treatment.

FDA-Approved

15 Brands

Allergy-Safe

8 Options

Single-Shot

4 Brands

Medicare

Covered

Quick Filters:

Bird or Egg Allergy?

Some gel shots are made from rooster combs and aren't safe if you have bird or egg allergies.

Avoid (avian): Synvisc, Monovisc, Gel-One, Orthovisc, Supartz, Hyalgan

Safe (non-avian): Euflexxa, Durolane, Gelsyn-3, Hymovis, GenVisc, and others

Read the full allergy guide

How Many Visits Can You Make?

Brands range from 1 to 5 injection visits. Research suggests 3-shot regimens may slightly outperform single-shots for some patients.

1 visit: Synvisc-One, Durolane, Monovisc, Gel-One

3 visits: Euflexxa, Gelsyn-3, Orthovisc, and more

Compare single vs multi-shot

Complete Brand Comparison

All 15 FDA-approved brands with key consumer information at a glance.

Brand	Injections	Source	Allergy Safe?	Insurance Status	Cost Range	Best For
Synvisc-One Sanofi	Single	Avian	No	Often Preferred	$800-$1,200 per injection	Busy patients who want convenient one-visit treatment and have no bird allergies
Monovisc Anika Therapeutics (DePuy Synthes / Johnson & Johnson)	Single	Biofermented	Yes	Variable	$700-$1,100 per injection	Patients wanting single-injection convenience, including those with bird or egg allergies
Durolane Bioventus	Single	Biofermented	Yes	Variable	$900-$1,300 per injection	Patients with bird allergies who want single-injection convenience, or those preferring non-animal products
Gel-One Zimmer Biomet	Single	Avian	No	Variable	$700-$1,000 per injection	Patients wanting single-injection treatment from a trusted orthopedic brand
Hymovis Fidia Pharma USA	2 shots	Biofermented	Yes	Variable	$600-$900 per course (2 injections)	Allergy patients who want fewer visits than 3-shot brands but prefer not to do single large dose
Euflexxa Ferring Pharmaceuticals	3 shots	Biofermented	Yes	Often Preferred	$600-$900 per course (3 injections)	Patients with bird allergies, those with flexible schedules, or when insurance prefers this brand
Gelsyn-3 Bioventus	3 shots	Biofermented	Yes	Step Therapy	$500-$800 per course (3 injections)	Cost-conscious patients, those with allergies, or when required by insurance step therapy
SynoJoynt Teva Pharmaceuticals USA	3 shots	Not disclosed	No	Step Therapy	$500-$750 per course (3 injections)	Patients seeking an affordable 3-injection option (confirm HA source first if allergy-prone)
Orthovisc Anika Therapeutics (DePuy Synthes / Johnson & Johnson)	3 shots	Biofermented	Yes	Typically Covered	$600-$900 per course (3 injections)	Patients wanting high molecular weight HA from a trusted brand, including those with bird or egg allergies
Triluron Fidia Pharma	3 shots	Avian	No	Step Therapy	$400-$700 per course (3 injections)	Patients without bird or egg allergies who need to satisfy step therapy requirements or are seeking a lowest-cost option
TriVisc OrthogenRx (Avanos)	3 shots	Biofermented	Yes	Step Therapy	$400-$650 per course (3 injections)	Step therapy compliance or budget-conscious patients with allergies
Visco-3 Zimmer Biomet	3 shots	Avian	No	Step Therapy	$400-$650 per course (3 injections)	Budget-conscious patients without bird or egg allergies completing step therapy
Supartz FX Bioventus	5 shots	Avian	No	Typically Covered	$600-$1,000 per course (5 injections)	Patients who prefer smaller, gradual doses and can commit to 5 weekly appointments
Hyalgan Fidia Pharma USA	5 shots	Avian	No	Typically Covered	$500-$900 per course (3-5 injections)	Patients who value longest track record and flexible scheduling
GenVisc 850 OrthogenRx (Avanos)	5 shots	Biofermented	Yes	Step Therapy	$500-$800 per course (5 injections)	Allergy patients who prefer gradual dosing with smaller individual injections