Synvisc-One × Aetna

Synvisc-One Insurance Coverage with Aetna

Everything you need to know about getting Synvisc-One viscosupplementation injections covered under Aetna, including requirements, costs, and approval steps.

Covered with Requirements

Aetna covers Synvisc-One when medical necessity and plan requirements are met.

Prior Authorization Required

Coverage Details

Coverage Status

Covered

Prior Authorization

Required

Estimated Cost

$100-$300 with Medicare/insurance

With insurance

Injection Schedule

Single injection

Can repeat Every 6 months as needed

Coverage Notes: Covered under most plans when medical necessity criteria are met. Policy varies by plan type.

Prior Authorization for HA Injections

Aetna requires prior authorization before Synvisc-One injections. Your provider's office typically handles this process. Here's what to expect:

1. Your doctor submits a prior authorization request with clinical documentation
2. Include X-ray evidence and records of failed conservative treatments
3. Approval typically takes 5-15 business days
4. If denied, you have the right to appeal (see below)

Coverage Requirements

Aetna typically requires the following for Synvisc-One coverage:

Diagnosis of knee osteoarthritis confirmed by imaging
Failed conservative treatment (NSAIDs, physical therapy)
Documented functional impairment
Prior authorization typically required

Expected Costs

Scenario	Estimated Cost
With Aetna coverage	$100-$300 with Medicare/insurance
Self-pay (without insurance)	$800-$1,200 per injection
Number of injections	Single injection
Repeat frequency	Every 6 months as needed

Costs are estimates and may vary based on your specific plan, location, and provider. Contact Aetna to verify your exact out-of-pocket costs.

How to Get Approved

Follow these steps to ensure your Synvisc-One treatment is approved by Aetna:

1 Request detailed explanation of benefits (EOB) with denial reason
2 Gather documentation of failed conservative treatments
3 Obtain letter of medical necessity from your physician
4 Include imaging reports confirming OA diagnosis
5 Submit appeal within 180 days of denial notice
6 Request peer-to-peer review with Aetna medical director

Other HA Brands & Aetna

Compare how Aetna covers other viscosupplementation brands:

Brand	Schedule	Source	Cost w/ Insurance	Details
Monovisc	Single injection	Avian	$100-$350 with insurance	View
Durolane	Single injection	Non-Avian	$150-$400 with insurance	View
Gel-One	Single injection	Avian	$100-$300 with insurance	View
Hymovis	2 weekly injections	Non-Avian	$100-$300 with insurance	View
Euflexxa	3 weekly injections	Non-Avian	$75-$250 with insurance	View
Gelsyn-3	3 weekly injections	Non-Avian	$75-$200 with insurance	View
SynoJoynt	3 weekly injections	Non-Avian	$75-$200 with insurance	View
Orthovisc	3-4 weekly injections	Avian	$100-$250 with insurance	View

Compare Insurance Plans for Synvisc-One

See how other insurance plans cover Synvisc-One:

What Your Doctor Needs to Submit

To get Synvisc-One approved by Aetna, your doctor's office will need to prepare the following documentation:

Knee Osteoarthritis Diagnosis

Confirmed diagnosis of knee OA using ICD-10 code M17 (or appropriate subcode). The documentation should include clinical findings from physical examination.

X-Ray Evidence

Radiographic imaging showing joint space narrowing, osteophytes, or other degenerative changes consistent with knee osteoarthritis. Images should be recent (within 6-12 months).

Failed Conservative Treatment

Records showing the patient tried and failed conservative treatments for at least 3-6 months. This includes physical therapy, exercise, weight management, OTC pain medications, and/or prescription anti-inflammatories.

Letter of Medical Necessity

A written statement from the treating physician explaining why Synvisc-One is medically necessary for this patient, including why conservative treatments were insufficient.

Prior Authorization Form

Complete the Aetna prior authorization form with all required fields. Include the J-code for Synvisc-One, units needed, and treatment location. Submit well in advance of the planned injection date.

Tip: Ask your doctor's office to confirm they have all required documentation before submitting to Aetna. Incomplete submissions are the most common reason for delays and initial denials.

Frequently Asked Questions

Does Aetna cover Synvisc-One?

Yes, Aetna typically covers Synvisc-One viscosupplementation injections for knee osteoarthritis when medical necessity is established. Coverage requires meeting specific requirements such as prior authorization and documentation of failed conservative treatments. The estimated cost with insurance is $100-$300 with Medicare/insurance.

How much does Synvisc-One cost with Aetna?

With Aetna coverage, the estimated out-of-pocket cost for Synvisc-One is $100-$300 with Medicare/insurance. This includes the Single injection injection schedule. Without insurance, the cost ranges from $800-$1,200 per injection. Your actual cost depends on your specific plan's deductible, copay, and coinsurance structure.

Do I need prior authorization for Synvisc-One with Aetna?

Yes, Aetna requires prior authorization before Synvisc-One injections. Your doctor's office will submit clinical documentation including your diagnosis, X-ray results, and records of failed conservative treatments. The process typically takes 5-15 business days. Plan ahead so approval is in place before your scheduled injection date.

What is the injection schedule for Synvisc-One?

Synvisc-One uses a Single injection schedule. It is manufactured by Sanofi and uses a avian (bird-derived) hyaluronic acid source with High (6,000 kDa) molecular weight. Treatment can be repeated Every 6 months as needed.

What if Aetna denies coverage for Synvisc-One?

If denied, you have the right to appeal. Ask for the denial reason in writing, then work with your doctor to submit an appeal including X-ray evidence of osteoarthritis, documentation of at least 3-6 months of failed conservative treatments (physical therapy, OTC pain relievers, exercise), and a letter of medical necessity from your doctor. Many initially denied claims are approved on appeal. You can also ask about alternative covered brands.