Monovisc Injection Cost: What You'll Pay in 2026 (With and Without Insurance)

Key Takeaways

Monovisc injection self-pay cost ranges from $500 to $1,000 depending on provider, location, and discounts
With Medicare Part B, patients typically pay the 20% coinsurance — roughly $80–$250 for the injection after meeting the annual deductible
Monovisc is billed under HCPCS code J7322 (hyaluronan or derivative, Monovisc, for intra-articular injection, 1 mg)
Monovisc is derived from bacterial fermentation (non-avian) — making it safe for patients with bird or egg allergies
As a single-injection treatment, Monovisc eliminates multiple office visit copays compared to 3–5 injection series brands
Monovisc and Durolane are the only two non-avian single-injection HA options on the market

Monovisc is a single-injection hyaluronic acid (HA) treatment for knee osteoarthritis made by Anika Therapeutics. If you’re weighing your treatment options and wondering what Monovisc will actually cost you — with insurance, without insurance, or through Medicare — this guide breaks it all down.

We cover 2026 pricing for every scenario: Medicare Part B, private insurance, and self-pay, plus practical tips for keeping your out-of-pocket costs as low as possible.

What Is Monovisc and Why Does It Cost What It Does?

Monovisc is a single-injection hyaluronic acid gel manufactured by Anika Therapeutics. It was FDA approved in 2014 and delivers 88 mg of highly purified sodium hyaluronate in a single 4 mL injection. The hyaluronic acid is produced through bacterial fermentation — not from animal sources like rooster combs.

This matters for cost because:

Single injection vs. series: Monovisc requires only one office visit, while brands like Euflexxa (3 injections) or Supartz FX (5 injections) require multiple visits — each with its own copay and office fee
Non-avian sourcing: Monovisc is produced through bacterial fermentation, making it safe for patients with bird or egg allergies — an important distinction shared only with Durolane among single-injection brands
High-dose formulation: At 88 mg per syringe (4 mL volume), Monovisc delivers more hyaluronic acid per injection than most competitors
Same manufacturer as Orthovisc: Anika Therapeutics also makes Orthovisc (a 3–4 injection series), giving providers flexibility to offer both single and multi-injection options from one trusted manufacturer

Monovisc Cost Without Insurance (Self-Pay)

Self-Pay Price Ranges for Monovisc (2026)

Cost Component	Range
Monovisc injection (medication only)	$500–$1,000
Office visit fee	$50–$200
Imaging guidance (recommended)	$100–$300
Total self-pay range	$650–$1,500

Why Prices Vary So Much

Monovisc pricing varies significantly because:

Provider markup: Clinics purchase Monovisc at wholesale and mark up the price — office-based practices typically charge less than hospital outpatient departments
Geographic location: Urban markets and high cost-of-living areas charge more than rural providers
Practice type: Orthopedic specialty clinics may price differently than pain management practices or primary care offices
Wholesale pricing: Direct-to-provider wholesale costs can be considerably lower than what patients see, but most savings stay with the practice unless you negotiate

Tip: Call providers and ask for their “self-pay price” for Monovisc — many offer discounted cash rates. Also, ask whether the imaging guidance (fluoroscopy or ultrasound) is included in the quoted price or billed separately.

Monovisc Cost With Medicare Part B

Medicare Coverage for Monovisc

Coverage status: Yes, Medicare Part B covers Monovisc (J7322)

Typical patient cost with Medicare:

Annual Part B deductible: $257 (2025; verify current year)
After deductible: You pay 20% coinsurance of the Medicare-approved amount
Medicare pays 80% of the approved amount

Estimated patient out-of-pocket:

If deductible already met: ~$80–$200 per injection (20% of the Medicare-approved amount)
If deductible not yet met: $257 + 20% of remainder

How Medicare Bills Monovisc

Medicare uses HCPCS code J7322 for Monovisc (Hyaluronan or derivative, Monovisc, for intra-articular injection, 1 mg per unit). Monovisc is supplied as a single 88 mg/4 mL syringe, so providers bill 88 units of J7322 per injection.

Your 20% coinsurance share depends on the Medicare-approved amount for J7322 in your region. Actual costs vary by geographic area, provider type, and whether imaging guidance is billed separately.

Medicare Coverage Requirements

Medicare requires documentation that:

You have a confirmed diagnosis of knee osteoarthritis

Conservative treatments have been tried without sufficient relief (physical therapy, NSAIDs, weight management)

Repeat treatments are at least 6 months apart

The injection is performed by a qualified provider

Medicare Advantage Plans

If you have a Medicare Advantage (Part C) plan, Monovisc coverage may differ from Original Medicare. Some Medicare Advantage plans require prior authorization, preferred networks, or specific prior treatment failure requirements. Always verify coverage with your specific plan before scheduling.

Monovisc Cost With Private Insurance

Most commercial insurance plans cover Monovisc for knee osteoarthritis when medical necessity criteria are met, similar to Medicare requirements.

Typical private insurance process:

Prior authorization is almost always required — your provider’s office handles this
Step therapy may require documentation of failed conservative treatments
Copay or coinsurance: Varies by plan — typically $50–$200 per injection
Deductible: If not yet met, you pay the full allowed amount until the deductible is reached

Tip: Have your provider’s office call to verify coverage and get prior authorization before your appointment. A reputable clinic handles this verification proactively.

Monovisc vs. Other Single-Injection Brands: Cost Comparison

Monovisc is one of four FDA-approved single-injection HA products. Understanding how its cost compares to alternatives helps you discuss options with your doctor.

Brand	Source	Self-Pay Estimate	Medicare Coverage	Allergy-Safe
Monovisc	Non-animal (bacterial)	$500–$1,000	Yes (J7322)	Yes — bird/egg safe
Durolane	Non-animal (bacterial)	$300–$1,465	Yes (J7318)	Yes — bird/egg safe
Synvisc-One	Avian (rooster comb)	$600–$1,200	Yes (J7321)	No
Gel-One	Avian (rooster comb)	$400–$900	Yes (J7320)	No

All four are covered by Medicare at similar payment levels. Monovisc and Durolane are the two non-avian single-injection options — making them the preferred choices for patients with bird or egg allergies. Your doctor can help determine which brand is best suited to your situation based on clinical factors, insurance formulary preferences, and availability.

Monovisc vs. Multi-Injection Series: True Cost Comparison

Single-injection Monovisc may look more expensive per dose, but the total cost often comes out similar to — or less than — a multi-injection series when you factor in all costs.

	Monovisc (Single)	Orthovisc (3–4 injections)	Supartz FX (5 injections)
Injections needed	1	3–4	5
Office visits	1	3–4	5
Medication cost (self-pay)	$500–$1,000	$900–$2,400 total	$500–$1,000 total
Office visit copays	1x	3–4x	5x
Time commitment	1 visit	3–4 weeks	5 weeks
Work/travel disruption	Minimal	Moderate	High

The hidden cost of series injections is time and visit copays. For Medicare patients with a $20 copay per visit, Monovisc saves $40–$60 vs. Orthovisc and $80 vs. Supartz FX in visit copays alone — partly offsetting any medication cost difference. For a detailed breakdown, see our Single Injection vs. Series comparison.

Hidden Costs to Budget For

When planning for Monovisc, account for these additional expenses beyond the injection itself:

Frequently Overlooked Costs

Office/consultation visit fee: $50–$200 (may be separate from injection fee)

Imaging guidance: $100–$300 if billed separately — studies show imaging guidance improves injection accuracy by 30%, so it’s worth the cost. Medicare covers fluoroscopy with the injection.

Pre-injection X-ray: If not already done, you may need knee X-rays ($100–$300 without insurance)

Follow-up visit: Some providers schedule a follow-up 4–6 weeks post-injection to assess response

Facility fees: Hospital outpatient departments charge a facility fee (often $200–$500+) on top of the injection fee — office-based clinics typically don’t

How to Reduce Your Out-of-Pocket Costs

For Medicare Patients

Supplement insurance: A Medigap (supplemental) policy covers most or all of the 20% coinsurance, potentially reducing your cost to near $0

Time your treatment: If you’ve already met your Part B deductible for the year, schedule before year-end to avoid starting fresh in January

Choose office-based providers: Hospital outpatient departments charge facility fees — office-based clinics are typically less expensive for Medicare patients

For Self-Pay Patients

Use a discount card: Programs like SingleCare, GoodRx, or RxSaver may reduce retail pricing — check current offers for Monovisc specifically

Ask about self-pay discounts: Many practices offer reduced rates for patients paying cash — ask directly before scheduling

Contact Anika Therapeutics: Reach out to Anika Therapeutics (Monovisc’s manufacturer) to ask about any available patient assistance or support programs

Consider alternative brands: If cost is a barrier, multi-injection series brands like Hyalgan or Supartz FX may have lower per-dose costs while providing similar relief

Frequently Asked Questions

Does Medicare cover Monovisc injections?

Yes. Medicare Part B covers Monovisc (billed as J7322) for knee osteoarthritis when medically necessary. You typically pay 20% coinsurance after meeting your annual Part B deductible of $257 (2025 figure). Your actual out-of-pocket cost per injection is typically $80–$250 depending on your deductible status and the provider’s Medicare-approved amount.

How much does Monovisc cost without insurance?

Without insurance, Monovisc costs approximately $500–$1,000 for the medication alone. The total self-pay cost including the office visit and imaging guidance typically ranges from $650–$1,500. Using a prescription discount card may reduce the medication cost — check current availability on SingleCare or GoodRx.

Is Monovisc safe for patients with bird or egg allergies?

Yes. Monovisc is produced through bacterial fermentation — not from avian (rooster comb) sources. This makes it safe for patients with bird or egg allergies. Monovisc and Durolane are the only two single-injection HA brands that are non-avian sourced.

How does Monovisc compare to Durolane in cost?

Monovisc and Durolane are comparable in cost and function. Both are non-avian single-injection HA treatments covered by Medicare. Monovisc self-pay pricing ($500–$1,000) falls within a similar range to Durolane ($300–$1,465). The best choice between them often comes down to your provider’s preference, insurance formulary coverage, and local availability. See our full Durolane cost guide for a detailed comparison.

How often can I get Monovisc and how does that affect annual cost?

Medicare allows repeat Monovisc treatment every 6 months when the previous course was effective. Annual cost for two treatments with Medicare (20% coinsurance, deductible already met) is typically $160–$500. Self-pay patients would pay $1,000–$2,000+ annually for twice-yearly treatment.

What’s the HCPCS code for Monovisc for insurance purposes?

Monovisc is billed using HCPCS code J7322 (Hyaluronan or derivative, Monovisc, for intra-articular injection, 1 mg per unit). One 88 mg/4 mL syringe = 88 units of J7322. The administration itself is typically billed under CPT 20610 (arthrocentesis, aspiration and/or injection, major joint).

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Last updated: March 2026. Pricing information reflects current market data and is subject to change. Medicare payment rates are updated annually. Always verify costs with your specific provider and insurance plan.

Medical Disclaimer: This article is for educational purposes only. Consult your healthcare provider to determine if Monovisc is appropriate for your condition and to verify current coverage with your insurance plan.