Two Orthopedic Giants, Two Single-Shot Options
Gel-One (Zimmer Biomet) and Monovisc (J&J) are both single-injection, avian-derived HA treatments. Both companies are orthopedic device leaders—so which formulation is better?
Side-by-Side Comparison
| Factor | Gel-One | Monovisc |
|---|---|---|
| Manufacturer | Zimmer Biomet | DePuy Synthes (J&J) |
| Volume | 3 mL | 4 mL |
| Molecular weight | High (500-730 kDa) | Higher (1-2.9M Da) |
| Source | Avian | Avian |
| Self-pay | $700-$1,000 | $700-$1,100 |
| Duration | 4-6 months | Up to 6 months |
Key Differences
Gel-One Advantages
- Smaller volume - 3 mL may mean less swelling
- Slightly lower cost - Marginally cheaper
Monovisc Advantages
- Higher molecular weight - Potentially better cushioning
- J&J backing - Comprehensive orthopedic expertise
Allergy Note
Both are contraindicated for bird/egg allergies. If you have avian allergies, consider Durolane (single-injection, non-avian) instead.
Making Your Decision
Choose Gel-One if:
- You prefer smaller injection volume
- Your provider stocks Zimmer Biomet products
- Slightly lower cost matters
Choose Monovisc if:
- You want higher molecular weight
- Your insurance prefers J&J products
- You’ve used Orthovisc successfully before
The Bottom Line
Both are solid single-injection options from orthopedic leaders. The differences are subtle—volume preference and insurance coverage will likely determine your choice.
Find Single-Injection Providers
Connect with specialists offering Gel-One and Monovisc.
Your information is secure. See our Privacy Policy and Terms of Service.
Thank You!
We've received your request. A provider specialist will contact you within 1-2 business days to help you find the right care.
What happens next?
- 1 We'll verify your insurance coverage
- 2 Match you with quality providers in your area
- 3 Contact you to discuss your options
Questions? Browse our guides:
How to Choose a ProviderHA Treatment Updates
Stay informed about knee osteoarthritis treatment options.
Join 10,000+ readers. No spam.